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Clinical and microscopic evidence of biofilm formation on titanium miniplates applied in maxillofacial surgery: a case series analysis

Bramasto Purbo Sejati, Ahmad Kusumaatmaja, M. G. Widiastuti, Tetiana Haniastuti

Case Reports in Plastic Surgery and Hand Surgery, 2025

4 citations

Abstract

Abstract Titanium miniplates, though biocompatible, often require removal due to infections (3–18%), primarily from Staphylococcus aureus. Biofilms, which resist antibiotics, drive persistent infections. We analyzed 10 infected miniplates via SEM, revealing dense polymicrobial biofilms, especially near screw holes. These structured microbial communities underscore the need for biofilm-targeted treatments to improve outcomes.

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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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