The role of sympathetic innervation and sympathomimetics in gastric secretion in vivo
Abstract
It can, I believe, be argued in summary that pentagastrin-stimulated acid and pepsin secretion from innervated or denervated fundic mucosa is inhibited by doses of epinephrine and isoproterenol that produce an unequivocal cardiac stimulation, but this cannot be said of either histamine-, bethanechol-, or methacholine-, or food-stimulated secretion. There is substantial old evidence that epinephrine and isoproterenol, in doses that depress the pentagastrin effect, actually augment that of histamine and cholinomimetics. Large doses, of course, inhibit unequivocally. Sympathectomy, chemical or surgical, seems to increase the responsiveness of the fundus to acid stimuli, but again there is little uniformity; both less acid following feeding, after sympathectomy, and more following propranolol have been reported. It would be rash to draw any conclusions from the action of either sympathetic stimulation or ablation. The evidence that beta-adrenergic blocking agents can prevent insulin-stimulated increases in gastrin is fairly good, but the evidence that these agents have any effect on food-stimulated gastrin levels (whether the food is a meal or sham) is not good. Almost every aspect of this subject remains confused and confusing. At the end of a paper such as this, most readers would expect conclusions, but any conclusions other than those given above would be invention or else bias. This subject, at present unfashionable for research, represents a black hole in our…
How strong is the evidence?
Evidence Hub reads this as a review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- A Survey on Knowledge Graphs: Representation, Acquisition, and Applications
- Toxicity of nanomaterials
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
- Halogen bonding (X‐bonding): A biological perspective
- Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
- Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.