Preliminary evaluation of full volume strain measurement in patellar cartilage following osteochondral allograft transplantation using magnetic resonance imaging
Abstract
Introduction: Articular cartilage (AC) defects of the patellofemoral joint (PFJ) are clinically challenging and mechanically demanding. Osteochondral allograft (OCA) transplantation is the standard treatment for large cartilage injuries; however, little is known about intra-tissue mechanics after transplantation. Computational models suggest that cartilage thickness mismatch concentrates stresses at donor-recipient interfaces in OCA-treated patella, but direct experimental evidence is scarce. Local cartilage strain is closely linked to tissue health; therefore, the goal of this work was to provide a preliminary, full volume assessment of patellar cartilage mechanics before and after OCA transplantation.
Methods: A displacement-encoded MRI sequence was used to quantify full volume displacement and strain fields in human patellar AC before and after OCA transplantation under controlled indentation. Intact cadaveric patellae (n = 4) were prepared, with three serving as recipients and one as donor. Samples were cyclically compressed in a custom-built rig using nominal displacements of 1 and 2 mm. The complex phase data were unwrapped and converted to displacements; the Green-Lagrange strain tensor was computed using a finite element framework in FEniCS. Minimum principal strain ( Emin ) and maximum shear strain ( Emaxshear ) were analyzed. Donor-recipient step-off distance, representing cartilage-level geometric mismatch, was measured at the graft interface.
Results: Global…
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