Peginterferon Beta-1a Reduces Conversion of MRI Lesions to Black Holes in Patients with Relapsing-Remitting Multiple Sclerosis (P3.091)
Abstract
Objective: To investigate the efficacy of peginterferon beta-1a in reducing conversion of new/newly enlarging T2 lesions and new gadolinium-enhancing (Gd+) lesions to black holes in patients with relapsing-remitting multiple sclerosis (RRMS).
Background: Subcutaneous peginterferon beta-1a 125 mcg every 2 weeks significantly improved imaging endpoints in patients with RRMS in the Phase 3 ADVANCE study.
Methods: Patients were randomized to treatment with peginterferon beta-1a every 2 or 4 weeks or placebo for Year 1; placebo-treated patients then received peginterferon beta-1a in Year 2 (delayed treatment). This post-hoc analysis compared black-hole conversion at the end of Year 2 between patients treated continuously every 2 weeks (n=408) and those receiving delayed treatment (n=393).
Results: Patients receiving every-2-week continuous treatment had lower mean numbers of new/newly enlarging T2 (2.6 vs 6.9; 4.1 vs 13.2) and new Gd+ (0.3 vs 1.6; 0.2 vs 1.6) lesions vs delayed treatment (Week 24; Week 48, respectively) compared with baseline. At Week 96, every-2-week continuously-treated patients had significantly fewer black holes converted from new/newly enlarging T2 lesions at Weeks 24 (0.76 vs 1.03 [95[percnt] CI 0.60-0.91], P =0.0037) and 48 (0.44 vs 0.99 [0.34-0.57], P P P =0.0003), compared with delayed-treatment patients. The proportion of patients who had black holes converted from new/newly enlarging T2 lesions was significantly lower in the continuous every-2-week arm…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 408 participants or records.
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