Dietary Intake Analyses for the Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis (PandrTB) Pharmacokinetic Sub-Study of the endTB and endTB-Q Clinical Trials
Abstract
Abstract Objective: Food consumed with anti-tuberculosis drugs can significantly affect their pharmacokinetics, potentially facilitating the development of resistance and impacting efficacy and safety. We describe dietary intake data from the PandrTB study, which evaluated the pharmacokinetics of bedaquiline, clofazimine, delamanid, levofloxacin, linezolid, moxifloxacin, and pyrazinamide in persons with drug-resistant TB. Dietary intake was recorded to assess the potential influence of concomitant food on drug absorption.
Results:: From 144 PandrTB study participants, 1030 meals were analyzed. The fat content of morning meals was
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