Antimicrobial resistance trends among dominant pathogens in six clinical departments of the Fourth Affiliated Hospital of Guangxi Medical University, 2020-2024
Abstract
OBJECTIVE: A review of antibiotic resistance and pathogen detection in six key clinical departments of our hospital was conducted between 2020 and 2024. Future hospital-acquired infection prevention, control strategies, and targeted medicine administration in relevant departments can be based on this study.
METHODS: We performed a retrospective analysis of bacterial isolates collected from six clinical departments in our hospital over the past 5 years, focusing on the number, distribution, and changing trends in antibiotic resistance rates among common infections.
RESULTS: 22,201 pathogenic bacterial strains were found in six departments over 5 years. Acinetobacter baumannii was the most common pathogen in the Intensive Care Unit. Pseudomonas aeruginosa in Pulmonary and Critical Care Medicine; Escherichia coli in Hematology; Haemophilus influenzae in Pediatrics; Escherichia coli in Orthopedics; Klebsiella pneumoniae in Neurosurgery. While Haemophilus influenzae showed increasing trends, the proportion of Pseudomonas aeruginosa among annually detected pathogens showed downward annual fluctuations (p 0.05). Haemophilus influenzae showed no resistance to ofloxacin or cefotaxime. The Intensive Care Unit had the highest resistance burden (p ≤ 0.002). The departments of Hematology, Neurosurgery, Orthopedics, and Respiratory and Critical Care Medicine are at an intermediate level; Pediatrics has the lowest burden of drug resistance.
CONCLUSION: The distribution of infectious…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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