A rare case of Legionella bozemanae leading to necrotizing pneumonia in an immunocompromised patient: a case study
Abstract
Legionella bozemanae is a rare organism of Legionella species that can cause mild fever to severe pulmonary pneumonia known as Legionnaires’ disease. It can also cause extra-pulmonary infections, particularly in immunocompromised patients although deadly outcome in immunocompetent has also been reported. Diagnosis is often delayed due to limitations of conventional methods such as culture, serology, and urinary antigen testing, making newer molecular methods more valuable for early detection. We report the case of a 68-year-old male with history of relapsed acute myeloid leukemia (AML) and Sweet’s syndrome who presented with worsening dyspnea to emergency department. For evaluation, CT chest and the Karius test were performed. Which confirmed L. bozemanae infection and lobar consolidation. Despite multiple courses of broad-spectrum antimicrobials, including fluoroquinolones (Levofloxacin), macrolides (Azithromycin), and beta-lactams (Amoxi-clav), his condition deteriorated. Repeat CT scan showed progressive bilateral consolidation with cavitation, this suggested progressing to necrotizing pneumonia. Invasive procedures were deferred due to profound pancytopenia. Escalation of antibiotics were done but the patient eventually succumbed to his illness. This case presents the diagnostic and therapeutic challenges of L. bozemanae infection in immunocompromised patient. Routine diagnostic methods often fail to identify this organism, whereas next-generation sequencing plasma…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.