Phytochemical Characterization and Neuropharmacological Assessment of Combretum indicum Methanolic Extract With Integrated Molecular Docking and Dynamics Simulation for Anxiety and Depression Therapy
Abstract
A study of the phytochemical composition, as well as in vitro and in vivo neuropharmacological activities of methanol extract of C. indicum (MECI) was carried out along with an in silico prediction. GC-MS/MS and FTIR results showed that the PEs contained various bioactive components like flavonoids, terpenoids, alkaloids, heterocyclic substances. In mice, MECI (200 and 400 mg/kg, i.p.) caused significant dose-dependent anxiolytic effects as indicated by the elevated plus maze test (increased duration and entries in open arms; 166.6 ± 14.71 s, ***p p C. indicum to manage anxiety and depression and thus endorse it as a multi-target natural therapeutic agent against the two mood disorders.
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