The Effect of Metformin and Medroxyprogesterone Acetate on Apoptotic Signaling Pathways in Wistar-Albino Rats With Induced Endometrial Hyperplasia
Abstract
The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.
Conditions: Apoptotic Signal Pathways in Endometrial Hyperplasia.
Primary outcome: Survivin Gene Expression Levels in Rat Uterine Tissue; Bcl-2 Gene Expression Levels in Rat Uterine Tissue; Bax Gene Expression Levels in Rat Uterine Tissue; c-Myc Gene Expression Levels in Rat Uterine Tissue; Caspase-9 Expression Levels in Rat Uterine Tissue.
Enrollment: 40 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 40 participants or records.
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