The Role of Metformin and Colesevelam in Human GLP-1 Secretion
Abstract
Our primary hypothesis is that bile acid sequestrant colesevelam and the antidiabetic drug metformin potentiates the secretion of the gut hormone glucagon-like peptide 1 (GLP-1).
Conditions: Type 2 Diabetes.
Primary outcome: Change in the gut hormone glucagon-like peptide 1 (GLP-1).
Enrollment: 12 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 12 participants or records.
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