Drug Level and Investigation of Novel Substances Indicated Downstream Effect in Glioblastoma
Abstract
Neuro-oncological trials may fail due to the drug never getting to the intended target (i.e. within the tumor micro environment). Also, changes' occurring in tumor cells when removed from patients and grown in-vitro is another limiting factor influencing the clinical success.
Important questions are therefore:
1. Does the drug get there?
2. Does the drug do what it is intended to do?
To improve chances of clinical success there is a need for rational and intelligent selection of potential drugs in future trials. This is an initiative for analyzing tumor concentration of preoperative administered repurposed drugs
Conditions: Glioblastoma.
Primary outcome: Bioavailabilty disulfiram; Bioavailabilty of metformin.
Enrollment: 3 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 3 participants or records.
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