Metformin versus insulin in gestational diabetes mellitus: a systematic review
Abstract
OBJECTIVE: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone.
DATA SOURCES: This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021.
STUDY SELECTION: Randomized clinical trials comparing metformin and insulin written in English, Spanish or Portuguese, with no time limit, were included.
DATA COLLECTION: Data was extracted from all the 7 articles and compared statistically when possible. Whenever data was not available or couldn't be statistically compared, the main results were described in detail.
DATA SYNTHESIS: Insulin alone is not superior than metformin with or without insulin on gestational diabetes mellitus.
CONCLUSION: There is a potential viability of using metformin as an alternative compared to insulin alone in the treatment of Gestational Diabetes Mellitus. However, all assessed outcomes have a very low level of certainty of evidence and more studies are necessary to support these findings.
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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