Compounding Metformin for Use in Functional Medicine
Abstract
The most common reason for metformin incompliance is due to its side-effect profile. Metformin can cause issues with the gastrointestinal tract and result in nausea, abdominal pain, diarrhea, bloating, or vomiting. The size of the metformin tablet, which is quite large, is another reason for incompliance. Compounding pharmacists can prepare a topical formulation of metformin, which helps eliminate the unwanted gastrointestinal side effects, as well as eliminate the incompliance due to the size of the tablet. The transdermal use of metformin also allows the patient to take a much lower dosage compared to oral metformin. An oral liquid formulation can also help resolve the issue of swallowing a large tablet for those patients who are diagnosed with dysphagia.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.