Recent advances in microfluidics and bioelectronics for three-dimensional organoid interfaces
Abstract
Organoids offer a promising alternative in biomedical research and clinical medicine, with better feature recapitulation than 2D cultures. They also have more consistent responses with clinical results when compared to animal models. However, major challenges exist in the longevity of culture, the reproducibility of organoid properties, and the development of non-disruptive monitoring methods. Recent advances in materials and microfabrication methods, such as 3D printing and compressive buckling, have enabled three-dimensional (3D) interfaces of microfluidics and bioelectronics to manipulate and monitor these biological models in exciting ways. These advanced systems have great potential for applications in drug delivery, personalized medicine, and disease modeling. We conclude with important future considerations to generate longevity using further technological development in organoid and spheroid models.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.