Exploring molecular interactions of drugs in different biologically active solvents: A comprehensive review for safe and efficient drug delivery systems
Abstract
In this review, the interactions between drugs and biologically active solvents have been extensively investigated due to their importance in optimizing pharmaceutical formulation performance for effective therapeutic efficacy and safe drug delivery. These interactions determine the molecular stability, reactivity and solubility of drugs in different biocompatible solvents. The knowledge about their absorption, distribution, metabolism, transport and bioavailability can be enhanced from their molecular interactions data. There have been reports of improved solubility and stability of drugs like metformin hydrochloride and hydralazine hydrochloride in aqueous solutions of carbohydrates and amino acids, which has an immediate effect on their bioavailability and treatment efficacy. Moreover, the COVID-19 pandemic has reestablished the importance of this review, as some drugs were clinically approved after proving their activity and efficacy during this phase. The antivirals favipiravir, remdesivir and two repurposed drugs, antimalarial hydroxychloroquine and metabolic inhibitor 2-deoxy-d-glucose (2-DG) were approved during this phase based on their available physicochemical data. These results established the clinical efficacy and dependency of drugs on their solvation environment, highlighting the pharmacological importance of studying molecular interactions in addition to their theoretical significance. The PRISMA (Preferred Reporting Items for Systematic Reviews and…
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