Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials
Abstract
Highlights • This is the largest meta-analysis of placebo-controlled GLP-1RA randomized controlled trials to report cardiovascular and renal outcomes among patients with and without diabetes mellitus.• GLP-1RAs significantly reduced MACE, all-cause mortality, CV mortality fatal and non-fatal stroke, coronary revascularization, and composite kidney outcome among patients with and without diabetes mellitus.• GLP-1RA reduced MACE in both sexes. Furthermore, GLP-1RA reduced MACE in patients with and without CVD history, in BMI above or below 30 kg/m2, and in patients with an eGFR level of below or above 60 ml/min/1.73m2.• The cardiovascular benefits from GLP-1RAs beyond weight loss is clear.• Health care professionals should consider prescribing GLP-1RAs to all eligible patients to improve cardiovascular and renal outcomes.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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