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Alterations of Exercise-Induced Carbohydrate and Fat Oxidation by Anthocyanin-Rich New Zealand Blackcurrant Are Associated with the Pre-Intervention Metabolic Function: A Secondary Analysis of Randomized Crossover Trials

M. E. Willems, M. Cook

Nutrients, 2025

71 participants · 5 citations

Abstract

Background/Objectives: Our studies have provided evidence for the alteration of exercise-induced metabolic responses by the intake of anthocyanin-rich New Zealand blackcurrant (NZBC) extract. In this secondary analysis of 10 studies, we examined the relationship between the pre-intervention exercise-induced respiratory exchange ratio and the blackcurrant-induced respiratory exchange ratio and substrate utilisation during exercise. Methods: Metabolic data of seven cohort and three case studies with females (n = 46) and males (n = 71), from recreationally active to ultra-endurance trained individuals that were dosed with different intake durations (acute to two-week intake) and dosages (105 to 420 mg of anthocyanins) of NZBC extract for walking-, running-, and cycling-induced effects, were included in the secondary analysis. Results: There was a strong positive correlation between the pre-intervention and blackcurrant-induced respiratory exchange ratio for females (Pearson r: 0.7972, p < 0.0001) and males (Pearson r: 0.8674, p < 0.0001). A moderate positive correlation was obtained for the relationship between the pre-intervention respiratory exchange ratio and changes in fat oxidation for females (Pearson r: 0.5311, p = 0.0001) and males (Pearson r: 0.3136, p = 0.002). In addition, a moderate negative correlation was obtained for the relationship between the pre-intervention respiratory exchange ratio and changes in carbohydrate oxidation for females (Pearson r: −0.3017, p =…

How strong is the evidence?

Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 71 participants or records.

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