Association between phenotypic characteristics of Escherichia coli and UTI recurrence in immunocompromised patients. A case-control study
Abstract
BACKGROUND
UTI recurrence is important in immunocompromised patients. There is a trend to study genotypically and phenotypically the role of certain virulence factors of Escherichia coli in the diagnosis of recurrent UTI. The main objective of this study was to determine if there is an association between phenotypic characteristics of E. coli and UTI recurrence in immunocompromised patients.
METHODS
A case-control study was performed on immunocompromised patients from Hospital Regional de Alta Especialidad del Bajío, Mexico. E. coli strains isolated from these patients were identificated and antimicrobial suceptibility test were performed. Strains with filamented cell morphology, mucoid colonial phenotype or biofilm production were considered cases. Strains without the characteristics were considered controls. UTI recurrence was identified based on clinical records. Odds Ratio was calculated to quantify the magnitude of association.
RESULTS
Association between filamented cell morphology and UTI recurrence was found (OR=2,19 95% CI 1,06 - 4,51; p=0,031). No association was found between mucoid colony morphology (p>0,05) or biofilm production (p>0,05) and UTI recurrence. Association between mucoid colony morphology and ESBL production was found (OR=3,09 95% 1,59 - 5,99; p<0,001).
CONCLUSION
Filamented cell morphology and mucoid colonial phenotype may have a possible diagnostic value for detection of UTI recurrence and antimicrobial resistance. Further diagnostic test studies…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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