Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study
Abstract
Abstract
Background: Migraine is a Primary Headache disorder, the exact aetiology of which till date is not established. Various neuroinflammatory conditions, cytokines, oxidative stress, neuropeptides and vasomotor changes have been hypothesized for the pathogenesis of migraine headache.
Aim and Objective: The aim of this study was to evaluate inflammatory and non-inflammatory marker levels in patients with migraine and compare with levels measured in controls.
Materials and Methods: This is a case control study of 45 cases of migraine between age group 15-50 years of either sex attending the outpatient department (OPD) of E.N.T, VIMSAR Burla between July 2019 to December 2019.After proper history and clinical evaluations, we analysed the serum level of inflammatory markers like Neutrophil-to-lymphocyte ratio (NLR), Malondialdehyde (MDA), C-Reactive Protein (CRP) and anti-inflammatory marker Adiponectin in migraine patients. We compared blood levels of these parameters of migraine patients with 45 controls attending the same OPD for ENT diseases other than migraine during the same period.
Results: The Unpaired t test between case and control groups shows significant increase in serum level of NLR,MDA and CRP in migraine patients compared to controls(P≤0.05).The case and control group did not show a significant difference in the value of adiponectin.
Conclusion: This study indicates that oxidative stress marker(MDA) and inflammatory markers like NLR and CRP may be potential…
How strong is the evidence?
Evidence Hub reads this as a case-control. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
Read the paper
Related studies
- Improving the translation of search strategies using the Polyglot Search Translator: a randomized controlled trial
- Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial
- Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
- A randomized, controlled trial of oral propranolol in infantile hemangioma
- Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study
- Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: a randomized controlled trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.