Managing pseudophakic bullous keratopathy with a topical rho kinase inhibitor: a case series
Abstract
Cataract surgery is common procedure globally. Among its adverse effects is pseudophakic bullous keratopathy (PBK), a corneal disorder characterized by stromal edema and the formation of epithelial and subepithelial bullae due to endothelial cell loss and decompensation. This case series examines the outcomes of using the topical Rho kinase inhibitor Ripasudil for managing pseudophakic bullous keratopathy (PBK) in three patients treated at Hadassah Medical Center. Clinical data, including visual acuity, intraocular pressure, central corneal thickness (CCT), and endothelial cell count, were extracted from electronic medical records before and after treatment. Patients were treated with topical Ripasudil for periods ranging from three to eleven months, three times daily, with adjustments based on disease severity. The first case involved a 66-year-old Jewish female, who presented with persistent corneal edema in the left eye. Following three months of Ripasudil therapy, the patient exhibited notable improvement in best-corrected visual acuity (BCVA), a reduction in central corneal thickness (CCT), and decreased central stromal edema. Similarly, the second case featured a 58-year-old Jewish male with a history of cataract surgery in the right eye performed 3 years prior at an external institution. After 3 months of Ripasudil treatment, the patient demonstrated measurable improvements in both BCVA and CCT, mirroring the therapeutic trend observed in the first case. In parallel,…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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