ECCT Modulates the Therapeutic Landscape for Advanced Lung Adenocarcinoma: A Case Series Demonstrating Efficacy Across EGFR-Mutant and Wild-Type Subtypes
Abstract
Lung cancer remains a leading cause of cancer-related mortality worldwide. Electro-Capacitive Cancer Therapy (ECCT), a non-invasive treatment utilizing alternating electric fields, has emerged as a promising adjunctive modality by selectively disrupting cancer cell mitosis. This study presents a case series evaluating the clinical outcomes of ECCT as an additive therapy for patients with advanced lung adenocarcinoma. Methods: Six patients with clinical stage IIIA to IVA pulmonary adenocarcinoma (two EGFR wild-type, four EGFR-mutant) were treated with ECCT concurrently with standard therapeutic modalities, including chemotherapy, radiotherapy, immunotherapy, or tyrosine kinase inhibitors (TKIs). ECCT was administered at a frequency of 100–150 kHz and a voltage of 20–30 Vpp, typically for 30 minutes to 4 hours daily, five days a week. Treatment response was evaluated through serial imaging (CT and PET-CT). Safety Monitoring and Adverse Event Assessment: All patients were monitored closely for adverse events (AEs) throughout the treatment period, following a prespecified safety monitoring protocol. All adverse events were prospectively documented and graded according to the Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. Special attention was paid to local skin reactions (dermatitis, erythema, or pain) occurring at the ECCT electrode application sites. Results: Five patients achieved a partial response (PR), and one maintained stable disease (SD), with…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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