Case Report: A Complex Case of Alloimmunisation and Transfusion Management in a 71-Year-Old Female
Abstract
Alloimmunisation against red cell antigens is a critical challenge in transfusion medicine, especially in patients with prior antigen exposure. We report a case of a 71-year-old female with severe anaemia, multiple alloantibodies (Anti-C and Anti-e), and a recent transfusion history. The case highlights the complexities of identifying compatible donor units and underscores the importance of advanced diagnostic methods, such as solid-phase red cell adherence (SPRCA), phenotyping, and elution techniques, in emergency transfusion scenarios. Proactive inventory management and extended antigen matching are discussed as key strategies for reducing alloimmunisation risk and improving patient outcomes.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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