Efficacy and safety of carbostyril in patients with community-acquired pneumonia
Abstract
Objective To investigate the efficacy and safety of carbostyril moxifloxacin hydrochloride (Avelox),Levofloxacin (Cravit) and Ciprofloxacin(Ciprobay) in patients with community-acquired pneumonia (CAP) and to provide the diagnosis reference.Methods One hundred twenty patients with CAP were randomly divided into three groups:Moxifloxacin group,Levofloxacin group and Ciprofloxacing group in an open clinical study.Clinical and bacteriological efficacy and safety were evaluated after 7 days of treatment.Results The total effective rate in Moxifloxacin,Levofloxacin and Ciprofloxacin treatment group was 93%,88% and 88%,respectively.The bacterial eradication rate in Moxifloxacin,Levofloxacin and Ciprofloxacin treatment group was 88.9%,76.5% and 73.3%,respectively.The adverse drug reaction rate was 7.5%,10% and 7.5%,respectively.There was no significantly difference in the effective rate and adverse drug reaction rate in the three groups(P0.05).Bacterial eradication rate of Moxifloxacin treatment group was better than Levofloxacin and Ciprofloxacin.Conclusion Moxifloxacin had a better bacterial eradication rate than Levofloxacin and Ciprofloxacin in the treatment of community acquired pneumonia.
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