Effects of acupuncture on the insulin signaling pathway and mitochondrial AMPK pathway in an animal model of type 2 diabetes mellitus: systematic evaluation and meta-analysis
Abstract
Previous studies of acupuncture for type 2 diabetes mellitus (T2DM) have focused on lowering blood glucose and improving symptoms; however, the mechanisms underlying these effects have not been systematically reviewed. Acupuncture can improve impaired glucose-lipid metabolism and correct insulin resistance (IR) by modulating relevant pathway cytokines, which are both key process in T2DM pathogenesis. The aim of this study was to quantitatively assess the efficacy of acupuncture in an animal model of T2DM. Three researchers identified animal studies of acupuncture intervention in T2DM by searching nine databases, including PubMed, Scopus, Embase, the Cochrane Library, Web of Science, Ovide Medline, BIOSIS Previews , Wan Fang, CNKI, and VIP. Literature that met the inclusion criteria was screened, required data were extracted, and meta-analysis was performed using RevMan 5.4 and Stata 17.0. A total of 31 studies with 619 animals were included—309 in the acupuncture group and 310 in the model group—all of which were male rodents. The mean quality score of the studies was 3.7, which indicated low quality. Meta-analysis showed that first acupuncture led to a significant reduction in body weight gain and hematological factors, and reduced food intake and water intake in T2DM animals. Second acupuncture significantly reduced blood glucose and serum insulin, increased insulin sensitivity, and decreased IR index in T2DM animals. Finally acupuncture had the following beneficial…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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