(465) The Future of Peyronie’s Disease Management: A Critical Review of Emerging and Investigational Therapies
Abstract
Abstract Introduction Introduction: Peyronie’s disease (PD) is an acquired fibrotic condition of the penis caused by microtrauma, leading to a dysregulated inflammatory response and the formation of fibrotic plaques in the tunica albuginea. This results in penile curvature, pain, and psychological distress, often impairing sexual function. Current treatments for PD have significant limitations: oral therapies show limited efficacy on curvature, and more effective invasive options such as collagenase Clostridium histolyticum carry high costs and potential adverse effects. This underscores an urgent need for novel therapeutic approaches that target the underlying pathophysiology of the disease. Objective Objective: To present a comprehensive overview and critical analysis of the most promising emerging therapies for PD, exploring their mechanisms of action, current development status, and the clinical challenges for their implementation. Methods Methods: A literature search was conducted in electronic databases (PubMed, Scopus, Web of Science, and ClinicalTrials.gov). Search terms combined “Peyronie’s disease” with keywords including “gene therapy,” “stem cell,” “shock wave therapy,” and “Tadalafil.” Boolean operators (AND/OR) were used to refine searches (e.g., “Peyronie’s disease” AND (“shock wave therapy” OR “Li-ESWT”)). The search was limited to original articles, systematic reviews, and meta-analyses published between 2024 and 2025 to ensure contemporary relevance.…
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