Low-Dose Silodosin for Premature Ejaculation: A Clinical Evaluation
Abstract
BACKGROUND & OBJECTIVE: Premature ejaculation (PE) is one of the most common male sexual disorders and mayoccur alone or in association with erectile dysfunction. Various psychological, behavioral, local, and pharmacologicaltreatment options are available; however, an ideal and universally accepted treatment regimen remains unavailable.This study aimed to evaluate the efficacy of silodosin 4 mg in the management of premature ejaculation.METHODOLOGY: This comparative study included 120 patients with PE, who were equally divided into two groups.Group A comprised 60 patients who received silodosin 4 mg two hours before sexual intercourse, while Group Bcomprised 60 patients who received a placebo capsule. The study period was six months, with patients followed forthree months. Pre- and post-treatment intravaginal ejaculation latency time (IELT), Premature Ejaculation Profile(PEP), and Clinical Global Impression of Change (CGIC) were recorded. Treatment-related adverse effects were alsodocumented. Informed consent was obtained, and ethical considerations were observed.RESULTS: The mean age was 29.6 ± 4.8 years in Group A and 29.8 ± 2.44 years in Group B. In Group A, 54 (90%) patientshad lifelong PE and 6 (10%) had acquired PE, whereas in Group B, 52 (86.6%) patients had lifelong PE and 8 (13.3%) hadacquired PE. In Group A, IELT increased significantly from less than one minute at baseline to 8.2 minutes aftertreatment with silodosin 4 mg. Significant improvement was also observed…
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