The value of 5-HT, leptin, and NE in the classification of premature ejaculation
Abstract
Background: While premature ejaculation (PE) can be divided into lifelong PE (LPE), acquired PE, natural variable PE (NPE), and subjective PE (SPE), there is no objective method to classify PE. Aim: To determine the value of serum serotonin (5-HT), leptin, and norepinephrine (NE) levels in the classification of PE. Methods: From July 2023 to July 2024, we recruited 150 participants and divided them into 4 groups: LPE (43 cases), NPE (32 cases), SPE (35 cases), and non-PE (40 cases) groups. All participants' baseline data, premature ejaculation diagnostic tool score, and intravaginal ejaculation latency time were investigated. In addition, all participants' serum 5-HT, leptin, and NE levels were measured. Outcome: Serum 5-HT, NE, and leptin levels were compared among all groups. Results: 543.0 ng/L, and leptin >19.8 ng/mL may be predictive indicators of LPE. Clinical Significance: Based on serum 5-HT, NE, and leptin levels, LPE can be distinguished from SPE and NPE, which provides an objective basis for the treatment of PE. Strengths and Limitations: There is no effective method to classify PE. The main limitation of this study is the limited sample size. Conclusion: The serum 5-HT, leptin, and NE levels in PE patients may contribute to the classification of PE.
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