In vitro activities of erythromycin, tetracycline and levofloxacin alone and in dual combinations against ureaplasma spp
Abstract
PURPOSE: It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas.
METHODS: The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay.
RESULTS: TET was the most active when the antibiotics were used alone. The combinations resulted in significantly decreased MICs for every agent compared with the use of single antibiotics (p 0.05), and decreased the MICs more significantly in the strains with an MIC ≥4 mg/l compared with MIC <4 mg/l, except for the TET-ERY pair. The ERY-LVX pair increased ERY MICs significantly in the MIC <4 mg/l group (p < 0.05). The combinations resulted in more beneficial MICs in strains where both agents had an MIC ≥4 mg/l compared with those where either had an MIC ≥4 mg/l, as well as in strains where either agent had an MIC <4 mg/l compared with those where both had an MIC <4 mg/l.
CONCLUSIONS: Drugs in dual combinations always give more beneficial MICs against ureaplasmas than one agent alone. Combinational benefits prefer strains with a higher initial MIC.
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