Combination vaccines for diphtheria, tetanus, pertussis, and Haemophilus influenzae type b
Abstract
The ability to combine the standard DTP and Haemophilus b conjugate vaccine considerably simplifies the childhood immunization schedule and process. In addition to reducing the number of immunizations by half, the combination product reduces administrative aspects associated with vaccination including tracking. Simplification of the immunization process should have a positive impact on the vaccine delivery and utilization. Perhaps more importantly, an ability to create combination vaccines will be critical for inclusion of new antigens appropriate for infant vaccines. The combination of DTP and HbOC reduces the number of immunizations routinely given at 2, 4, and 6 months of age by half. Since it is unlikely that parents or pediatricians will accept more than two shots per visit, this reduction is critical. As new vaccines are licensed for such important childhood pathogens as Streptococcus pneumoniae and respiratory syncytial virus, designing stable combination products will become even more critical. Having stated that, we must also not lose site of the fact that combination products must meet the criteria for stability, safety, and efficacy comparable to the separately delivered products. These considerations are not trivial. In the development of Tetramune (DTP-HbOC), stability of the product and consistency of the immune response were critical design parameters for both the preclinical and clinical research. Likewise, the experience with other DTP-Haemophilus b…
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Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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