Review of antidepressants and antipsychotics drugs: Trends, efficacy, and new directions
Abstract
This review considers the shifting landscape in antidepressant and antipsychotic drugs, with an emphasis on usage patterns, therapeutic potency, and directions for the future of psychiatric treatment. It considers the history of drug development from the initial monoamine-targeting drugs through the newer classes of drugs such as the SSRIs, SNRIs, and antipsychotic drugs. It addresses the contemporary patterns of global prescribing, off-label prescribing, and increasing usage among special groups, as well as important challenges such as treatment resistance, adherence, and presence of side effects. Emerging new medicines such as rapid-acting antidepressants (e.g., ketamine), long-acting injectable drugs, pharmacogenetics, and digital psychiatry are presented as new breakthroughs. The review highlights the value of evidence-based, tailored drug therapy and encourages expanded interdisciplinarity for ongoing research towards improved safety, access, and patient-focused outcomes in psychiatric pharmacotherapy.
Read the paper
Related studies
- Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2)
- In silico and in vitro studies: investigating the chemical composition, DFT, molecular docking, and dynamic simulation of Satureja candidissima (Munby) Briq essential oil as a potential antibacterial agent
- Quercetin combined with ciprofloxacin and gentamicin inhibits biofilm formation and virulence in Staphylococcus aureus
- In silico study of the mechanism of action, pharmacokinetic and toxicological properties of some N-methylanthranilates and their analogs
- Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABAA Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies
- 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as D3R-Selective Ligands for 3D-QSAR, Docking and Molecular Dynamics Simulation Studies
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.