Gamma-Irradiated Honey: Its Medicinal Efficacy and Biological Activities for Burned Skin in a Rat Model
Abstract
Honey, with its diverse chemical, physical, and antibacterial properties, exhibits significant variability depending on the floral origin of the nectar source. Likewise, its therapeutic potential in the context of healing cutaneous burn injuries shows remarkable variation. In this comprehensive
two-week study, four distinct honey varieties (Nigella Sativa Honey - NSH, Moringa Honey - MOH, Sidr Honey - SIH, and Pumpkin Honey - PUH), along with Vaseline, were administered as therapeutic interventions in a rat model. The study covered a range of parameters, including wound contraction,
neovascularization rates, malondialdehyde (MDA) content determined via colorimetry, and assessments of breaking strength and dry tissue weight. Agar diffusion tests were conducted to evaluate the efficacy of treatments against Streptococcus pyogenes and Klebsiella pneumonia strains.
On the 15th day, the MOH-treated group exhibited the most rapid wound contraction at 84.58%, while the Vaseline-treated group showed the slowest at 68.40%. Notably, neovascularization was most pronounced in MOH-treated animals (45.01%), followed by SIH (42.73%), PUH (36.15%), and NSH (31.17%).
In contrast, the Vaseline group had the lowest rate at 15.53%. Histological examinations revealed that animals treated with Vaseline had fewer oval-shaped cells compared to honey-treated counterparts. The highest weight loss occurred in the Vaseline group at 42.25% on the 15th day. MDA content
was highest in SIH-treated animals…
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