Radiologically Measured Renal Pelvis Urine Density Is Associated with Severe Infectious Complications After Ureteroscopy for Ureteral Stones: A Post Hoc Analysis of a Multicenter Prospective Study
Abstract
Background and objective: Finding reliable and easy-to-obtain indicators of severe infectious complications after ureteroscopy represents a major clinical need. This study aimed to assess the association between Hounsfield units (HUs) in renal pelvis urine and severe infectious complications in patients with ureteral stones and asymptomatic hydronephrosis following ureteroscopy.
Methods: In this post hoc analysis of a multicenter prospective trial, renal pelvis urine density (RPUD) was measured via non-contrast-enhanced computed tomography. Severe complications (septic shock, urosepsis, and systemic inflammatory response syndrome) were recorded. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by multivariable logistic regression.
Key findings and limitations: Among 601 patients, 9.5% (57/601) developed severe infectious complications. After adjustment, each one HU unit increase in RPUD was associated with 54% higher odds of severe infectious complications (adjusted OR = 1.54; 95% CI: 1.37-1.73; p p = 0.2). Gender (female vs male, adjusted OR = 3.55; 95% CI: 1.57-8.02; p = 0.002), hydronephrosis grade (G3 or G4 vs G1 or G2, adjusted OR = 4.86; 95% CI: 1.89-12.5; p = 0.001), and mean stone density (lower vs higher, adjusted OR = 0.996; 95% CI: 0.994-0.997; p < 0.001) were also independently associated with severe infectious complications.
Conclusions and clinical implications: This study demonstrates a positive linear association between renal pelvis…
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 601 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.