Concurrent chemoradiotherapy with cisplatin and vinorelbine for stage III non-small cell lung cancer
Abstract
INTRODUCTION: Concurrent chemoradiotherapy with full doses of cisplatin-based chemotherapy is standard treatment for inoperable stage III non-small cell lung cancer (NSCLC). Although many platinum-based two drug combinations with third-generation agents are difficult to combine fully with thoracic radiotherapy (TRT), a phase I study reported a full dose of cisplatin (CDDP) plus 80% dose of vinorelbine (VNR) was successfully combined with concurrent TRT.
METHODS: Between October 2000 and October 2004, 73 patients with inoperable stage III NSCLC treated with CDDP, VNR, and concurrent TRT were retrospectively analyzed. Patients were treated with CDDP 80 mg/m on day 1 and VNR 20 mg/m on days 1 and 8 every 4 weeks. Radiotherapy was administered concurrently in cycle 1. The total radiation dose was 60 Gy in 30 fractions. Common Terminology Criteria for Adverse Events version 3.0 were used to assess treatment-related adverse events.
RESULTS: Median age was 63 years (40-78). Twenty-nine patients had adenocarcinoma, 63 were male, 47 ECOG PS 1, and 47 stage IIIB. Median chemotherapy cycle was 2.0. Objective response rate was 93% and median survival time was 21 months. Three-year overall survival rate was 33%. Infield control rate was 71%. The most common grade 3 or 4 adverse event was leukocytopenia (67%). Only 3 patients (4%) experienced grade 3 esophagitis. One patient died of radiation pneumonitis 87 days after completion of chemoradiotherapy.
CONCLUSIONS: Concurrent…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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