Anaesthetic and cardiorespiratory effects of romifidine/ketamine combinations in cats
Abstract
OBJECTIVE: To study the anaesthetic and cardiorespiratory effects of intramuscular (IM) administration of different combinations of romifidine and ketamine in cats.
STUDY DESIGN: Prospective, randomized, cross-over experiment. Animals Seven healthy adult cats weighing (mean +/- SD) 3.4 +/- 0.7 kg and aged 4.6 +/- 3.2 years.
METHODS: Animals received romifidine 100 microg kg(-1) with ketamine 7.5 (R100/K7.5) and 10 mg kg(-1) (R100/K10), romifidine 200 microg kg(-1) with ketamine 5 (R200/K5), 7.5 (R200/K7.5) and 10 mg kg(-1) (R200/K10) by IM injection. The time required to perform orotracheal intubation (IT) was measured and the ease of intubation assessed. The onset of anaesthesia (OA), duration of anaesthesia (DA) and anaesthesia recovery times (AR) were measured. Analgesia and muscle relaxation scores were recorded every 5 minutes for 60 minutes after OA. Heart rate, systolic arterial pressure, arterial haemoglobin saturation, respiratory rate, end-tidal carbon dioxide and oesophageal temperature were also measured.
RESULTS: The IT, OA and DA were not significantly different between the treatments. The analgesia and muscle relaxation scores were similar between all treatments at most time points. The cardiorespiratory variables were not significantly different between the treatments in most cases. The adverse effects were dose dependent and similar to those previously described for other combinations of alpha(2)-agonists and ketamine.
CONCLUSIONS AND CLINICAL RELEVANCE:…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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