Fenoterol-ipratropium nebulization in infants with obstructive bronchial syndrome
Abstract
A double blind prospective study was done in 120 infants with acute obstructive bronchial disease. One half of them received combined fenoterol-ipratropium solution by inhalation in three different dose schedules while the other half was given inhalation normal saline solution for comparative purposes. Statistical analysis showed a significant difference in favor of fenoterol-ipratropium treatment over controls as to severity of bronchial obstruction, days of recovery and the need of additional bronchodilator drugs. However, no significant differences in the response of these parameters were noted among patients receiving different dose schedules of fenoterol-ipratropium. The combination of fenoterol-ipratropium showed a beneficial bronchodilator effect in patients with acute obstructive bronchial disease.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 120 participants or records.
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