Initial selection of oral contraceptives
Abstract
A prospective, randomized trial compared client experiences with three popular oral contraceptives--Triphasil, Ortho-Novum 7/7/7 and Ortho-Novum 1/35. After one year, no significant relationship was found between the contraceptive prescribed and either breakthrough bleeding or satisfaction with the medication. The monophasic formulation, Ortho-Novum 1/35, was associated with amenorrhea more often.
Differences in breakthrough bleeding, amenorrhea, and patient compliance among users of monophasic (Ortho-Novum 1/35) and triphasic (Triphasil and Ortho-Novum 7/7/7) oral contraceptives (OCs) were investigated in a prospective study at a Michigan family planning clinic. 377 (79%) of the women originally enrolled in the study completed the 1-year study period. There was no association between failure to return to the clinic at the required intervals and type of OC prescribed. The percentage of women experiencing breakthrough bleeding in their 1st year of use was 18.4% among Ortho-Novum 7/7/7 users, 17.8% among Ortho-Novum 1/35 users, and 11.2% among Triphasil users; the percentages of women reporting amenorrhea were 3.0%, 12.8%, and 0.0%, respectively. The degree of patient satisfaction was 82.8% for Ortho-Novum 7/7/7, 90.7% for Ortho-Novum 1/35, and 85.2% for Triphasil. No significant correlations were detected between age, weight, or height and the 3 variables under investigation. These findings indicate that Ortho-Novum 1/35, the monophasic formulation, is more frequently…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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