The bactericidal action of penicillin in vivo: the participation of the host, and the slow recovery of the surviving organisms
Abstract
Article1 September 1950THE BACTERICIDAL ACTION OF PENICILLIN IN VIVO: THE PARTICIPATION OF THE HOST, AND THE SLOW RECOVERY OF THE SURVIVING ORGANISMSHARRY EAGLE, M.D., RALPH FLEISCHMAN, ARLYNE D. MUSSELMANHARRY EAGLE, M.D., RALPH FLEISCHMAN, ARLYNE D. MUSSELMANAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-3-544 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough penicillin is known to be actively bactericidal, there is reason to believe that its therapeutic activity is not determined solely by that direct bactericidal action, and that other factors may supervene in vivo. Thus, Jawetz6found that, in a mouse streptococcal infection bacteria continued to die long after penicillin in demonstrable amounts had disappeared from the serum; and clinical experience has established the fact that penicillin is effective even when given so infrequently that for a considerable period between injections it is not present in bactericidal concentrations.11, 12, 13, 14These observations would seem to minimize the importance of...Bibliography1. ParkerMarsh RFHC: The action of penicillin on staphylococcus, J. Bact. 51: 181, 1946. CrossrefGoogle Scholar2. ParkerLuse RFS: The action of penicillin on staphylococcus: further observations on the effect of a short exposure, J. Bact. 56: 75, 1948. CrossrefMedlineGoogle Scholar3. EagleMusselman HAD: The slow recovery of bacteria from…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- Penicillins for Treatment of Pneumococcal Pneumonia: Does In Vitro Resistance Really Matter?
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.