Cimetidine and/or antacid for the control of gastric acidity in pediatric burn patients
Abstract
A retrospective study was performed to assess the therapeutic efficacy of cimetidine and antacid, alone and in combination, for the control of gastric acidity and bleeding in pediatric burn patients. The frequency of pH values no greater than 3.5 was significantly greater in the cimetidine group than in the antacid group, and the combined regimen did not enhance the effectiveness of therapy. In all groups, pH values no greater than 3.5 were associated with a significantly higher incidence of positive guaiac tests. In four patients studied prospectively, 63% of the administered dose was detected in the urine 8 h later, compared to the previously reported 24-h delay for normal, healthy adults. Rapid clearance of cimetidine might explain the decreased efficacy of this drug in burn patients. Dosage and schedules for antacid prophylaxis in pediatric burn patients require further study.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2)
- In silico and in vitro studies: investigating the chemical composition, DFT, molecular docking, and dynamic simulation of Satureja candidissima (Munby) Briq essential oil as a potential antibacterial agent
- Quercetin combined with ciprofloxacin and gentamicin inhibits biofilm formation and virulence in Staphylococcus aureus
- In silico study of the mechanism of action, pharmacokinetic and toxicological properties of some N-methylanthranilates and their analogs
- Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABAA Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies
- 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as D3R-Selective Ligands for 3D-QSAR, Docking and Molecular Dynamics Simulation Studies
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.