Curative Treatment of Brain Arteriovenous Malformations Combining Endovascular and Surgical Approaches Consecutively
Abstract
BACKGROUND: Brain arteriovenous malformations (AVMs) pose a significant treatment challenge, with options including microsurgical resection, endovascular embolization, radiosurgery, or combinations thereof. We present our experience with a curative strategy combining complete endovascular treatment followed by microsurgical resection under the same anesthesia session, without relying on a hybrid operating room.
METHODS: We reviewed consecutive patients with AVM who underwent endovascular treatment and microsurgical resection in a single anesthesia session (COMBI-AVM protocol) from December 2017 to July 2022. Primary endpoints were angiographic AVM obliteration status and modified Rankin Scale score at last follow-up. AVMs were graded by the Spetzler-Martin (SM) system, comparing low-grade (SM I, SM II, SM III with nidus <3 cm) and high-grade (SM III with nidus ≥3 cm, SM IV, SM V) AVMs.
RESULTS: Of 46 patients with AVM, 34 had low-grade (73.9%) and 12 had high-grade (26.1%) AVMs. The protocol feasibility was 100%. Median anesthesia time was 8.7 hours (interquartile range, 7.6-10.6). Complete AVM removal was achieved in 45 patients (97.8%), with no recurrences at late (>6 months) follow-up in any of the 32 patients (71.1%) with available follow-up data. Good clinical outcomes (modified Rankin Scale score ≤2) were seen in 91.3% of patients. Disabling treatment-related complications occurred in 4 patients (8.6%), including 1 death (2.2%).
CONCLUSIONS: Combining maximal…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 46 participants or records.
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