Pre-treatment prediction of microsatellite instability in colon cancer: a nomogram model combining clinicopathological features and pre-treatment CT-based radiomics
Abstract
BACKGROUND: Determining microsatellite instability (MSI) status in colon cancer is crucial for selecting treatment strategies in advanced stages. Thus, accurately identifying MSI status before treatment is essential.
OBJECTIVE: This study aims to evaluate the utility of nomogram model that integrates clinicopathological indicators and pre-treatment CT-based radiomics features for predicting DNA mismatch repair deficiency (dMMR) /microsatellite instability (MSI) status in colon cancer prior to treatment.
METHODS: A total of 201 colon cancer patients who had undergone preoperative contrast-enhanced CT scans were categorized into the dMMR/MSI group or the proficient Mismatch Repair (pMMR)/Microsatellite Stable (MSS) group based on surgical pathology results. Multivariate logistic regression was applied to identify independent clinical predictors. The least absolute shrinkage and selection operator (LASSO) regression was applied for dimensionality reduction of radiomics features. Clinical, radiomics, and nomogram models were established through logistic regression analysis based on the risk clinicopathological predictors and radiomics features.
RESULTS: Multivariate logistic regression identified patient age, pericentric lymph node metastasis, and CA72-4 levels as significant (P < 0.05). Four radiomic features were selected to construct the radiomics model. In the training set, the AUC values for the clinical model, Rad score, and combined model were 0.86, 0.89, and 0.94,…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 201 participants or records.
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