The effect of surfactant therapy on the oxygen treatment of premature infants with HMD
Abstract
UNLABELLED: A retrospective study is carried out, including 61 premature newborns, admitted to the Intensive Care Unit of State Maternity Hospital from 1994 to 1996. The aim of the study is to establish the influence of surfactant therapy on the duration of oxygen therapy and on the incidence of BPD. Criteria for entry: birth weight below 1500 grams, gestational age up o 32 weeks, clinical signs and x-ray proof of RDS.
EXCLUSION CRITERIA: major inborn malformations and IVH--grams i.v.. Newborns are divided in 3 groups: 27 babies treated with Curosurf, 10 babies treated with Exosurf and 24 babies who received no surfactant. Results show that surfactant treated babies spent shorter time on ventilator support and oxygen therapy as a whole, the difference having high statistic level of significance in the Curosurf group. Surfactant therapy leads to lowering the incidence of oxygen dependency at 36 weeks post conception, especially in Curosurf treated babies.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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