The combined associations of excess body weight, hypertension, and hypertriglyceridemia with hyperglycemia among nondiabetic older adults in regional China
Abstract
To investigate the separate and combined associations of excess body weight (EBW), hypertension (HTN), and hypertriglyceridemia (HTG) with hyperglycemia among non-diabetic adults aged 60 years and above in regional China. In this cross-sectional study conducted in 2023, 26,769 non-diabetic individuals aged 60 years and older were selected from Nanjing municipality, China. Body weight and height, blood pressure, fasting plasma triglycerides, and glucose were objectively measured, while socio-demographic attributes, lifestyle and behaviors, and disease history were self-reported. The outcome variable was hyperglycemia. Independent variables included EBW, HTN, HTG, and their combinations. Mixed-effects logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the separate and combined associations of EBW, HTN, and HTG with hyperglycemia. Among all participants, the prevalence of hyperglycemia was 16.3%, while 14.0%, 57.2%, and 27.8% had obesity, HTN, and HTG, respectively. After adjusting for potential confounders, individuals with EBW, HTN, or HTG were independently more likely to experience hyperglycemia compared to those without the corresponding condition. Participants with any two-factor combinations of these three conditions had a higher risk of hyperglycemia than those with only one. Moreover, individuals with the three conditions had substantially greater odds of hyperglycemia than those with any two-factor…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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