Neurocognitive Performance and Depressive Mood in People With HIV: The Role of Prescription Opioids Use
Abstract
BACKGROUND: The issue of potential adverse reactions or toxicities of pharmacotherapies used for chronic diseases in people with HIV is still to be clarified.
METHODS: This study targeted potential effects on neurocognition and mood from prescription opioids, alone or in combination with other classes of drugs, using cross-sectional data from 400 participants in the multicenter CNS HIV Anti-Retroviral Therapy Effects Research study.
RESULTS: We found that prescription opioid use alone was not associated with neurocognitive performance (β = -1.05, Standard error [SE] = 0.80, P = 0.18) or depressive mood (β = -0.08, SE = 0.19, P = 0.65). However, if used in combination with antidepressants, prescription opioid use significantly correlated with reduced neurocognitive performance (β = -2.58, SE = 1.17, P = 0.03). Also, combinations of prescription opioids and antidepressants with statins (β = -2.87, SE = 1.49, P = 0.05) or lipid-lowering agents other than statins (β = -2.88, SE = 1.39, P = 0.04) were associated with lower neurocognitive performance. The interaction of prescription opioid use with the presence of distal sensory polyneuropathy (DSP) was significant ( P = 0.03). In those without DSP, prescription opioid use was associated with better neurocognitive performance (β = 4.25, SE = 2.13, P = 0.04); by contrast, in those with DSP, the direction of the effect was reversed. No modifying effect on neurocognition was obtained considering distal neuropathic pain, lifetime…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 400 participants or records.
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