A case of type 4 advanced gastric cancer with aplastic anemia successfully treated with neoadjuvant chemotherapy and surgical resection
Abstract
We have experienced a case of Type 4 advanced gastric cancer with aplastic anemia, which had been treated with S-1 and intra-peritoneal docetaxcel combination chemotherapy followed by surgery. Fifteen years ago, a 51-year-old woman was diagnosed as aplastic anemia but she ignored any treatment due to no symptoms. A Type 4 advanced gastric cancer was detected with a chief complaint of stomach heaviness in December 2009. Peritoneal lavage cytology was performed before treatment and showed positive peritoneal dissemination. Two courses of S-1 and intra-peritoneal docetaxcel combination chemotherapy was administered but no serious side effects occurred during the therapy. Total gastrectomy with D2 lymph node dissection was successfully undergone. The final stage was ypT4aN3H0M0P1, Stage IV. It appeared that S-1 and intraperitoneal docetaxcel combination chemotherapy was a safe regimen for a patient with aplastic anemia in our case.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2)
- In silico and in vitro studies: investigating the chemical composition, DFT, molecular docking, and dynamic simulation of Satureja candidissima (Munby) Briq essential oil as a potential antibacterial agent
- Quercetin combined with ciprofloxacin and gentamicin inhibits biofilm formation and virulence in Staphylococcus aureus
- In silico study of the mechanism of action, pharmacokinetic and toxicological properties of some N-methylanthranilates and their analogs
- Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABAA Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies
- 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as D3R-Selective Ligands for 3D-QSAR, Docking and Molecular Dynamics Simulation Studies
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.