A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection
Abstract
All patients who presented with epigastric pain and dyspeptic symptoms will undergo endoscopic gastric biopsies.
The patients will be subjected to: Full history taking, clinical examination, liver function tests, renal function tests, CBC, INR, abdominal ultrasonography.
About 200 patients diagnosed to have H. pylori by infection by microscopically examined, endoscopic gastric biopsies will be enrolled in our study.
All available formalin fixed and paraffin embedded tissue blocks of gastric endoscopic biopsies will be resectioned and stained with Haematoxylin and Eosin. Modified Giemsa stain, and Alcian blue/ PAS stain will be used for verification of Helicobacter pylori and demonstration of intestinal metaplasia respectively.
Biopsies will be classified using the Updated Sydney system of classification of gastritis
Conditions: H. Pylori Infection.
Primary outcome: Eradication of H. pylori infection after treatment.
Enrollment: 200 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 200 participants or records.
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