Efficacy and safety of persimmon leaf formulated with green tea and sophora fruit extracts (BLH308) on hair growth: A randomized, double‐blind, placebo‐controlled clinical trial
Abstract
Recent research suggests that persimmon leaf extract (PLE) has an effect on inflammatory skin diseases. Previously, PLE is revealed to inhibit not only nitric oxide production but also inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) expression levels in mouse macrophages in vitro. Moreover, it significantly reduced IL‐6 production and 5α‐reductase expression in human follicle dermal papilla cells (HFDPCs). This study aimed to determine whether the PLE‐containing BLH308 complex improves hair growth in clinical trials.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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