Prevalence of potential drug-drug interactions in bone marrow transplant patients
Abstract
OBJECTIVE: To assess the prevalence of potential drug-drug interactions (DDIs) in bone marrow transplantation (BMT) patients at the time of pre-infusion (day -1), to describe the potential DDIs and assess their frequency and severity.
SETTING: The study was developed in a tertiary care hospital in São Paulo, Brazil.
METHOD: Cross-sectional study based on examining the medical prescriptions from the pre-infusion day (day -1) of 70 BMT patients. Potential DDIs were analyzed using Drug-Reax(®) and categorized according to levels of severity, evidence, and onset (rapid and delayed). Only interactions of major or moderate severity were included in the potential DDI analysis.
MAIN OUTCOME MEASURE: Prevalence of potential DDIs in patients during the preinfusion phase of BMT.
RESULTS: Data were analysed for 70 BMT patients. The median age was 36.5 years; 52.9% (37) of the patients were male, and 65.7% (46) were undergoing autologous BMT. The patients received a median of 8 drugs each. Up to 128 potential DDIs were detected, 60.0% (42) of patients had at least 1 potential DDI and 21.4% (15) were exposed to at least 1 major potential DDI. The most commonly involved drugs were cyclosporine (9, 28.1%), phenytoin (8, 25%) and fluconazole (5, 15.6%). Most potential DDIs had moderate severity (110, 85.9%), a pharmacokinetic mechanism (67, 52.3%), and were classified as delayed onset (106, 82.8%). For major interactions, fluconazole + sulfamethoxazole/trimethoprim, diazepam + fentanyl,…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 70 participants or records.
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