Antibiotic susceptibility situation of environmental Legionella pneumophila isolates in Southern Germany
Abstract
Antimicrobial resistance is an emerging problem in hospitals and long-term healthcare facilities. Early detection of susceptibility pattern changes in pathogenic bacteria can prevent treatment failures. Therefore, this study chose to investigate the antibiotic susceptibility situation of Legionella pneumophila isolates from hospitals and long-term healthcare facilities in Southern Germany. Serogroups and minimal inhibitory concentrations (MICs) of nine antibiotics were determined from 41 L. pneumophila strains. In total, 28% of the collected strains belonged to the more pathogenic serogroup 1, whereas 72% belonged to serogroups 2-14. Among the tested antibiotics, rifampicin had the lowest MIC90 value. The MIC90 values can be summarized in the following order: rifampicin < levofloxacin < moxifloxacin < ciprofloxacin < clarithromycin < azithromycin < erythromycin < doxycycline < tigecycline.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.