Clarithromycin Versus Levofloxacin-Based Triple Regime in Stool Antigen-Positive Helicobacter Pylori Patients: A Quasi-Experimental Study in Islamabad
Abstract
Objective: To compare the eradication rate and adverse effects of clarithromycin versus levofloxacin-basedtriple regimen in patients with positive stool antigen test for Helicobacter pylori.Study Design: Quasi-experimental study.Place and Duration of Study: This study was conducted at the Medicine Department of Federal GovernmentPolyclinic Hospital, Islamabad, Pakistan, from 1st January 2024 to 30th December 2024.Methods: A total of 270 patients with positive stool antigen tests for H. pylori were included using nonprobabilityconvenience sampling. Patients were allocated into two groups with 135 patients each: Group I received clarithromycin, omeprazole, and amoxicillin, whereas Group II received levofloxacin, omeprazole, and amoxicillin. In each group, 70 patients completed the regimen for 14 days, and 65 patients took it for 10 days. A repeat stool antigen test was performed 4 weeks after completion of the regimen. Data was analyzed using the Statistical Package for the Social Sciences (SPSS) version 26.Results: Helicobacter pylori were eradicated in 117 (86.7%) and 99 (73.3%) patients with levofloxacin- and clarithromycin-based regimens, respectively (P-value=0.006). Significant eradication was achieved in 53 (81.5%) with levofloxacin versus 43 (66.2%) with a clarithromycin-based regimen, with a 10-day regimen. The eradication rates were significantly higher with levofloxacin than with a clarithromycin-based regimen (91.4% versus 80%) with a 14-day regimen. The adverse…
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