Delayed-Onset Hypoglycemia After Levofloxacin Use in a Diabetic Patient
Abstract
We discuss the case of a patient with diabetes on long-term glipizide and stable glucose management who presented with delayed-onset hypoglycemia 6 weeks after initiating levofloxacin for osteomyelitis. The patient presented with neuroglycopenic symptoms, including dysarthria, slurred speech, and syncopal episodes. Serum glucose level was 35 mg/dL, and C-peptide was markedly elevated at 12.42 ng/mL. Hypoglycemia resolved immediately after D50 administration. Discontinuation of glipizide while on levofloxacin did not result in any new hypoglycemic episodes. In previously documented cases, hypoglycemia occurred within days or less than a week after initiating levofloxacin. This report represents an interesting case of delayed-onset hypoglycemia after initiating levofloxacin in a stably managed diabetic patient on long-term glipizide secretagogue.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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